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More than 300 million peripheral IV (PIV) catheters are sold each year in the United States alone, and 60% to 90% of hospitalized patients require an IV catheter during their hospital stay. Intravenous (IV) catheters are now reported to be the single most common source of bacteremia and fungemia, yet infections associated with short peripheral catheters receive very little attention. Advances in training, monitoring, and documentation, as well as adoption of multifaceted policy “bundles,” have improved overall safety and reduced costs. This content is intended for Health Care Professionals in the United States.