Esophagectomy is the mainstay of cure for esophageal cancers, but one of the most feared complications of this surgical procedure is anastomotic leakage, as it can increase morbidity, length of hospital stays, and mortality. This episode discusses a retrospective cohort study that evaluated the impact of a powered circular stapler on post-operatory complications following esophagectomy with intrathoracic anastomosis. This content is intended for Health Care Professionals in Southeast Asia.